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KMID : 0605820130200030168
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Korean Journal of Pediatric Infectious Diseases
2013 Volume.20 No. 3 p.168 ~ p.177
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Clinical and Epidemiological Characteristics of Human Metapneumovirus Infections, in Comparison with Respiratory Syncytial Virus A and B
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Kang Soo-young
Hong Che-Ry
Kang Hyun-mi
Cho Eun-Young
Lee Hyun-Ju
Choi Eun-Hwa
Lee Hoan-Jong
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Abstract
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Purpose: To identify the clinical and epidemiological characteristics of human metapneumovirus infections (hMPV) in children compared to respiratory syncytial virus A (RSV A) and B (RSV B).
Method: A retrospective review of medical records was performed in 36 patients with hMPV infection, 106 with RSV A infection, and 51 with RSV B infection, from September 2007 to July 2012.
Results: The peak incidence of hMPV infection was observed in May, whereas for RSV infections in November and December. hMPV infection occurred in older patients compared to RSV A and B infection (29.9±32.5 months vs. 13.6±15.4 months, P <0.001; 29.9±32.5 months vs. 12.1±13.5 months, P <0.001, respectively). hMPV infection was more often associated with fever compared to RSV A (97.2% vs. 67.9%, P <0.001), while wheezing was less frequent compared to RSV A and B infection (16.7% vs. 47.2%, P =0.001; 16.7% vs. 37.3%, P =0.037, respectively). hMPV infection was more often diagnosed as pneumonia compared to RSV A infection (72.2% vs. 50.0%, P =0.047) while bronchiolitis was less frequent than in RSV A (5.6% vs. 34.9%, P =0.001) or RSV B infection (5.6% vs. 29.4%, P =0.006). In addition, intravenous antibiotic was more often prescribed for patients with hMPV infection than those with RSV A and B (69.4% vs. 39.6%, P =0.002; 69.4% vs. 43.1, P =0.015, respectively).
Conclusion: This study identified characteristics of hMPV infection compared to RSV A and B infection. Seasonality in spring, higher age group, and higher proportion of pneumonia in hMPV infections may be a useful guide for management of respiratory viral infections in children.
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KEYWORD
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Human metapneumovirus, Respiratory syncytial virus
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